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Managing Depression in Clinical Practice
3
Contents
5
Author biographies
7
Preface
9
Chapter 1 Classification, causes, and epidemiology
11
Different types of depression
11
Depressive disorders
11
Causes of depression
15
Epidemiology and natural history
18
References
20
Chapter 2 Depression in different types of patients
21
Depression in children
21
Depression in elderly people
22
Depression in women
23
Depression in patients with comorbid medical conditions
24
References
25
Chapter 3 Diagnosis
26
Signs and symptoms of depression
26
Differential diagnosis
28
The patient examination and interview
29
Laboratory tests for co-occurring illnesses
33
References
34
Chapter 4 Principles of therapy
35
Goals of treatment
35
Rating scales for assessment of outcomes
36
Acute treatment outcomes
36
Medium- and long-term treatment outcomes
38
Treatment options
39
Nonspecific effects and placebo
39
Specific treatment options
39
Choice of treatment
40
Thresholds for benefit from specific treatments
40
Choice between specific treatments
42
Practicalities of treatment
43
Evaluation of risk, education, and agreeing treatment
43
Special populations
45
Children and adolescents
45
Elderly people
45
Pregnancy and breastfeeding
46
Initiating treatment
46
Monitoring and adjusting treatment
47
Service structure in delivery of treatment
48
Factors affecting response to treatment
49
References
50
Chapter 5 Medications
52
Selective serotonin reuptake inhibitors
53
Serotonin and norepinephrine reuptake inhibitors
55
Venlafaxine
55
Duloxetine
56
Milnacipran
56
Monoamine receptor antagonist drugs
56
Trazodone and nefazodone
56
Mirtazapine
57
Norepinephrine reuptake inhibitors
58
Reboxetine
58
Dopamine reuptake inhibitors
58
Bupropion (amfebutamone)
58
Tricyclic antidepressants
59
Monoamine oxidase inhibitors
61
Other drugs
62
New compounds
62
Augmentation strategies
63
Specific adverse effects of antidepressants
63
Serotonin syndrome
63
Antidepressant discontinuation syndrome
63
Suicidality
64
References
65
Chapter 6 Other treatments
66
Psychotherapy for depression
66
Combination psychotherapy and psychopharmacotherapy for depression
68
Physical treatments
71
Electroconvulsive therapy
71
Phototherapy
73
Other physical treatments
73
Vagus nerve stimulation
74
Transcranial magnetic stimulation
74
Deep brain stimulation
75
Lifestyle and complementary therapies
75
Exercise
76
St John’s wort
77
Omega-3-fatty acids
77
Acupuncture
78
References
80
Chapter 7 Management of treatment nonresponse
83
Assessment and principles of management
83
Assessment
83
Principles of management
84
Definitions: treatment nonresponse and treatment-resistant depression
85
Medication strategies
86
Dose increase
86
Switching treatment
86
Combining treatments
87
Psychological treatment strategies
88
Physical treatment strategies
89
References
90
Chapter 8 Continuation and maintenance treatment
91
Goals of continuation/maintenance treatment
91
Phases of treatment
91
Medication
92
Psychological treatments
93
Physical treatments
94
Risk factors for relapse and recurrence
94
Longer-term treatment in practice
94
References
96
Index
97
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