Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases - A New Perspective

Preface

Acknowledgments

Introduction

Contents

About the Author

Invasive Studies of the Parameters Regulating Ocular Physiology and Vision

“In Vivo” Manometric Studies of the Steady State Intraocular Pressure and the Intraocular Pressure Pulse in Animals and Man

The Rate of Formation of the Aqueous Humor

The Steady State Intraocular Pressure/ Flow Relations in Dead and Living Animal and Human Eyes

Homeostasis, Autoregulation, and Relative Ischemia

The Pressure/Volume Relation in Eyes of Dead and Living Animal and Human Eyes

The Ocular Perfusion Pressure and Its Influence on the Intraocular Pressure Pulse

Direct and Indirect Measurements of Ocular Blood Flow in Anesthetized and Conscious Animals and Humans

The Morphology and Hydrodynamics of the Chamber Angle Draining the Aqueous Humor

The Sympathetic Nerve Innervation of the Eye and the Actions of the Adrenergic Neuron Transmitter Norepinephrine on Intraocular Pressure and Ocular Blood Flow

Manometric Studies on the Intraocular Pressure and Vascular Circulation in Ophthalmic Disease

References

Noninvasive Studies on the IOP, PA, and Blood Flow Autoregulation in Healthy and Diseased Eyes

Indirect Measurements of the Intraocular Pressure and the Intraocular Pressure Pulse

The Effect of Posture and Corneal Thickness on the Measurement of the Intraocular Pressure

The Langham Pneumatic Analogue and Digitized Tonometers

The Calibration of the Intraocular Pressure and the Intraocular Pressure Pulse using the Langham Pneumatic Tonometer

The Theory of the Langham Tonometer

The Intraocular Pressure/Pulse Amplitude Relation in Healthy Animal and Human Eyes

The Intraocular Pressure/Pulse Amplitude Relation and Loss of Autoregulation in Ocular Diseases

Autoregulation of the Intraocular Pressure and the Ocular Blood Flow

The Evaluation of Ocular Ischemia and the Loss of Autoregulation for the Early Detection of Ocular Vascular Diseases

The Action of Drugs on Ocular Blood Flow and on the Intraocular Pressure/ Pulse Amplitude Relation

The Confluence and Integration of Therapies Based on Modulation of the Intraocular Pressure and Ocular Blood Flow

Longitudinal Therapeutic Studies

References

Ophthalmodynamometry, the Ophthalmic Arterial Pressure and the Effect of Increased Vascular Resistance Proximal and Distal to the Ophthalmic Artery on Ocular Blood Flow, the IOP/ PA Relation and Vision

The Ophthalmic Arterial Pressure, the Intraocular Pressure/ Pulse Amplitude Curve, and Their Relations to the Ocular and Cerebral Circulations

Ophthalmodynamometry

Autoregulation of the Intraocular Pressure and Blood Flow in the Human Eye

Objective Measurement of the Diastolic and Systolic Ophthalmic Arterial Pressures

The Ophthalmic Arterial Pressure in Healthy Subjects

The Relation Between the Ophthalmic Arterial Pressure and the Intraocular Pressure/ Pulse Amplitude Relation

Modulation of the Intraocular Pressure/ Pulse Amplitude Relation in Subjects with Stenosis of the Internal Carotid Artery

Alzheimer's Disease and the Eye

The Ocular Perfusion Pressure and the Visual Threshold

Concepts and New Perspectives

References

Index